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The evaluation of vitamin K status in children with febrile seizure

Kürşat Bora Carman1, Yasemin Karal2, Gül Gülen Mert3

  • 1Department of Pediatric Neurology, Eskişehir Osmangazi University School of Medicine, Eskişehir, Turkey.

Balkan Medical Journal
|October 13, 2020
PubMed

Insights

Children with febrile seizures show higher serum vitamin K levels compared to healthy controls. These findings suggest a potential role for vitamin K in the underlying mechanisms of febrile seizures in pediatric patients.

Area of Science:

  • Pediatric Neurology
  • Biochemistry
  • Immunology

Background:

  • Febrile seizure is the most common childhood neurological disorder.
  • Its exact pathophysiology remains unclear.
  • Vitamin K has demonstrated roles in nonhematological and inflammatory conditions.

Purpose of the Study:

  • To investigate serum vitamin K levels in children diagnosed with febrile seizures.
  • To explore the relationship between vitamin K and inflammatory markers in febrile seizures.

Main Methods:

  • A prospective case-control study was conducted across 8 Turkish cities.
  • Serum levels of Vitamin K1, Vitamin K2, TNF-alpha, IL-1 beta, and IL-6 were measured using ELISA.
  • 155 children (84 with febrile seizures, 71 controls) were enrolled.

Main Results:

  • Children with febrile seizures exhibited significantly higher serum Vitamin K1 and K2 levels than controls.
  • Vitamin K levels correlated positively with inflammatory markers (TNF-alpha, IL-1 beta, IL-6).
  • First-time febrile seizure patients had higher vitamin K levels than those with recurrent seizures.

Conclusions:

  • Elevated serum vitamin K levels are observed in children experiencing febrile seizures.
  • These findings may offer insights into the etiopathogenesis of febrile seizures.
  • Further research is warranted to understand the specific role of vitamin K.
Abstract

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