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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
08:44

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

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Clinical manifestations and laboratory results of 61 children with infectious mononucleosis

Yanming Wu1, Suli Ma1, Lingjun Zhang1

  • 1Department of Pediatrics, People's Hospital of Shanghai Pudong New District, Shanghai University of Medicine and Health Sciences, Shanghai, China.

The Journal of International Medical Research
|October 13, 2020
PubMed

Insights

Infectious mononucleosis presents differently in children based on age. Younger children experience more nasal symptoms, while older children show higher liver enzymes and atypical lymphocytes, impacting clinical decisions.

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Immunology

Background:

  • Infectious mononucleosis (IM), a common viral illness, presents with varied symptoms.
  • Understanding age-specific clinical manifestations is crucial for accurate diagnosis and management in pediatric populations.

Purpose of the Study:

  • To investigate and delineate the clinical manifestations of infectious mononucleosis in children across different age groups.
  • To identify age-related differences in symptoms and laboratory findings associated with IM in pediatric patients.

Main Methods:

  • Retrospective analysis of clinical data from 61 pediatric patients diagnosed with infectious mononucleosis between May 2015 and April 2019.
  • Patients were categorized into three age strata: 1-3 years, 4-6 years, and 7-14 years for comparative analysis.

Main Results:

  • Common symptoms included fever (98.3%), tonsillitis (100%), cervical lymphadenopathy (98.3%), tonsillar exudate (83.6%), hepatomegaly (37.7%), and splenomegaly (42.6%).
  • Younger children (1-6 years) exhibited more pronounced nasal obstruction, whereas older children (7-14 years) presented with elevated alanine aminotransferase and increased atypical lymphocytes.
  • Disease onset peaked in early childhood and preschool ages (37.7% each).

Conclusions:

  • Clinical manifestations of infectious mononucleosis in children vary significantly with age.
  • Recognizing these age-dependent differences is essential for effective clinical decision-making and patient care.
Abstract

Keywords:
Epstein–Barr virusage stagingclinical manifestationsinfectious mononucleosislaboratory resultsretrospective analysis

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