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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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'Posture second' strategy predicts disability progression in multiple sclerosis.

Letizia Castelli1, Maria Esmeralda Quartuccio2, Serena Ruggieri3

  • 1Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 13, 2020
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Summary
This summary is machine-generated.

Patients with multiple sclerosis (MS) using a

Keywords:
Multiple sclerosisbalancecognitive-posture interferenceforce platform

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Area of Science:

  • Neurology
  • Biomedical Engineering
  • Rehabilitation Medicine

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease affecting balance and mobility.
  • Assessing balance control is crucial for predicting disease progression in MS patients.
  • The dual-task cost (DTC) of balance quantifies the impact of cognitive load on postural stability.

Purpose of the Study:

  • To investigate the predictive value of the dual-task cost (DTC) of balance for disability progression in multiple sclerosis (MS).
  • To determine if a 'posture second' strategy, indicated by high DTC values, predicts future disability in MS.
  • To explore the potential of DTC as an early indicator of MS progression.

Main Methods:

  • 168 patients with MS were assessed using a force platform to measure the DTC of balance during a Stroop test.
  • Disability progression was monitored over a median follow-up of 3.5 years.
  • Statistical analyses controlled for demographic and clinical characteristics to identify predictors of progression.

Main Results:

  • Disability progression occurred in 27% of MS patients within the follow-up period.
  • A 'posture second' strategy, defined by DTC values exceeding those of healthy controls, significantly predicted disability progression.
  • This predictive relationship remained significant after adjusting for other factors.

Conclusions:

  • The dual-task cost (DTC) of balance, particularly the 'posture second' strategy, is a potential novel and easily measurable tool for predicting multiple sclerosis progression.
  • This finding may aid in early identification of patients at higher risk for disability advancement.
  • Further research can validate DTC as a routine clinical assessment for MS management.