Moderate-Intensity Continuous Training Improves FGF21 and KLB Expression in Obese Mice
Yingzhe Xiong1, Yan Chen1, Yao Liu1
1Research Center of Physical Education and Health Science, Division of Sports Science and Physical Education, Tsinghua University, Beijing, 100084, China.
Biochemistry. Biokhimiia
|October 13, 2020
Summary
Moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) both aid weight loss. MICT more effectively boosts Fibroblast Growth Factor 21 (FGF21) and β-Klotho (KLB) expression in key metabolic tissues.
Area of Science:
- Metabolic research
- Exercise physiology
- Obesity research
Background:
- Fibroblast growth factor 21 (FGF21) and β-Klotho (KLB) are crucial in managing overweight and obesity.
- Understanding factors influencing FGF21 and KLB expression is vital for developing effective weight management strategies.
Purpose of the Study:
- To investigate the impact of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on FGF21 and KLB expression.
- To compare the efficacy of MICT and HIIT in modulating obesity-related markers in mice on a high-fat diet.
Main Methods:
- Mice were fed a high-fat diet to induce obesity.
- Three groups were established: sedentary (SED), MICT, and HIIT.
- Exercise interventions (MICT and HIIT) were conducted over eight weeks, with continued high-fat diet.
Main Results:
- Both MICT and HIIT reduced high-fat diet-induced weight gain and increased serum FGF21 levels.
- HIIT significantly decreased body weight and serum triglyceride (TG) levels.
- MICT demonstrated superior enhancement of FGF21 and KLB mRNA and protein expression in the liver, brown adipose tissue (BAT), and muscle.
Conclusions:
- Both MICT and HIIT offer benefits for weight loss and metabolic health.
- MICT appears more effective in upregulating key metabolic regulators FGF21 and KLB in specific tissues, suggesting distinct roles in obesity management.
