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Obesity01:24

Obesity

992
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
992

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Related Experiment Video

Updated: Dec 6, 2025

Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
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The aging mouse microbiome has obesogenic characteristics.

Dana Binyamin1, Nir Werbner1, Meital Nuriel-Ohayon1

  • 1Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.

Genome Medicine
|October 13, 2020
PubMed
Summary
This summary is machine-generated.

The gut microbiome changes with age, contributing to obesity. Transplanting aged mouse gut bacteria into younger mice induced obesity-related traits, suggesting the microbiome can drive weight gain.

Keywords:
AgingFecal microbiota transplantationMetabolismMicrobiome

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Area of Science:

  • Microbiology
  • Gerontology
  • Metabolism

Background:

  • Aging is associated with physiological decline, increased disease risk, and altered gut microbiota composition.
  • The gut microbiome undergoes natural changes during the aging process.
  • Understanding the gut microbiome's role in age-related metabolic changes is crucial.

Purpose of the Study:

  • To investigate the influence of the gut microbiome on metabolic parameters in adult versus aged mice.
  • To determine if the gut microbiota of aged mice possesses obesogenic characteristics.
  • To assess the causal role of the aged gut microbiome in metabolic dysfunction.

Main Methods:

  • Collected fecal and blood samples from adult (100-300 days) and aged (550-750 days) mice.
  • Analyzed gut microbiome composition using QIIME2.
  • Performed fecal microbiota transplantation from adult and aged mice into young germ-free mice to assess phenotypic transfer.

Main Results:

  • Distinguishable gut microbiomes were observed between adult and aged mice.
  • Aged mice exhibited higher body weight, increased fat mass, decreased lean mass, and elevated insulin and leptin levels compared to adult mice.
  • Mice receiving fecal microbiota from aged donors showed increased fat mass, higher insulin levels, greater food consumption, and a higher respiratory quotient.

Conclusions:

  • The gut microbiota of aged mice possesses obesogenic properties.
  • The gut bacterial population alone is sufficient to induce some obesity-related manifestations.
  • Targeting the gut microbiome may offer therapeutic strategies for age-related metabolic disorders.