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Thrombocytopenia associated with transcatheter closure of giant patent ductus arteriosus

Lei Liu1,2, Peng Yue1,2, Xiaolan Zheng1,2

  • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.

Cardiology in the Young
|October 13, 2020
PubMed

Insights

A high occluder size to body weight ratio (≥1.6) predicts thrombocytopenia after giant patent ductus arteriosus closure. This ratio also predicts longer hospital stays, with medication offering no benefit.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Interventional Cardiology

Background:

  • Thrombocytopenia is a known complication after giant patent ductus arteriosus (PDA) closure.
  • Risk factors for post-procedural thrombocytopenia remain under-researched.

Purpose of the Study:

  • To identify risk factors for thrombocytopenia following PDA closure.
  • To determine predictors of hospitalization duration after PDA closure.

Main Methods:

  • Retrospective review of patients undergoing PDA closure with large occluders (≥10/12 mm) from January 2013 to June 2019.
  • Analysis of patient characteristics and follow-up data.
  • Univariate analysis, ROC curves, and linear regression to identify risk factors and predictors.

Main Results:

  • Thrombocytopenia occurred in 17.5% of patients (32/183).
  • The ratio of occluder disc size to body weight was an independent predictor of thrombocytopenia (AUC=0.691, p=0.001).
  • A ratio > 1.5895 indicated higher risk; each unit increase predicted ~2.86 additional hospitalization days.

Conclusions:

  • A ratio of occluder size to body weight > 1.6 is associated with guaranteed thrombocytopenia.
  • Increased ratio correlates with extended hospitalization; medication does not shorten stay or improve platelet count.
Abstract

Keywords:
Thrombocytopeniagiant patent ductus arteriosusrisk factorstranscatheter closure

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