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Related Concept Videos

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Ventricular reshaping with a beating heart implant improves pump function in experimental heart failure.

Daisuke Onohara1, Daniella M Corporan1, Takanori Kono1

  • 1Structural Heart Research & Innovation Laboratory, Carlyle Fraser Heart Center, Emory University Hospital Midtown, Atlanta, Ga.

The Journal of Thoracic and Cardiovascular Surgery
|October 13, 2020
PubMed
Summary

Restoring the physiological shape of the left ventricle after myocardial infarction with a beating heart implant significantly improves heart pump function and reduces wall stress, aiding recovery from heart failure.

Keywords:
adverse remodelinghelical fibersischemic cardiomyopathysphericityventricular shape

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Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Myocardial infarction causes left ventricular remodeling, leading to a spherical shape, reduced pump efficiency, and potential congestive heart failure.
  • The spherical left ventricle experiences increased wall stress, contributing to disease progression.

Purpose of the Study:

  • To investigate if restoring physiological ventricular shape using a beating heart implant can improve pump function after myocardial infarction.
  • To assess the impact of ventricular reshaping on cardiac mechanics and cellular structure.

Main Methods:

  • Myocardial infarction was induced in rats, leading to left ventricular dilatation and spherical remodeling.
  • Rats were randomized to receive a transventricular beating heart implant for reshaping or serve as controls.
  • Echocardiography, invasive hemodynamics, and histopathology were used to evaluate pump function and structural changes over 12 weeks.

Main Results:

  • Ventricular reshaping significantly reduced end-diastolic volume and sphericity, restoring physiological shape and lowering wall stress.
  • Reshaped hearts demonstrated improved pump function and ventricular-vascular coupling over the 12-week follow-up.
  • Cardiomyocyte cross-sectional area increased, with cells becoming less elongated in the reshaped group.

Conclusions:

  • Restoring the physiological conical shape of the postinfarction left ventricle through reshaping significantly enhances long-term pump function.
  • Beating heart implant technology offers a promising approach for treating heart failure caused by ventricular remodeling.