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Updated: Dec 6, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Targeting the glycan of receptor binding domain with jacalin as a novel approach to develop a treatment against
Senthilnathan Rajendaran1, Arunchalam Jothi1, Veerappan Anbazhagan1
1School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu 613 413, India.
Abstract:
In silico analysis revealed that a lectin, jacalin from jackfruit seeds, recognizes a glycosylated region of the receptor-binding domain (RBD) of SARS-CoV2. Jacalin binding induces conformational changes in RBD and significantly affects its interaction with human angiotensin-converting enzyme 2. The result may open up exploration of lectin-based strategies against COVID-19.
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