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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
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Assessment of the Willis circle flow changes and the severity of degenerative aortic stenosis and cognitive

Jakub Baran, Tadeusz Przewłocki, Jakub Podolec

    Kardiologia Polska
    |October 13, 2020
    PubMed

    Insights

    Elderly patients with degenerative aortic stenosis (DAS) show reduced cerebral blood flow (CBF) and increased arterial stiffness. However, cognitive decline is linked to comorbidities, not CBF changes.

    Area of Science:

    • Cardiovascular Medicine
    • Neurology
    • Geriatrics

    Background:

    • Degenerative aortic stenosis (DAS) frequently coexists with cognitive decline in elderly individuals, impacting patient prognosis.
    • Understanding the relationship between DAS and cognitive function is crucial for managing elderly patients.

    Purpose of the Study:

    • To evaluate intracranial blood flow parameters in the Willis circle and cognitive status in patients with DAS.
    • To investigate the association between cerebral blood flow (CBF) and cognitive function in moderate and severe DAS.

    Main Methods:

    • Utilized ultrasonography to assess Willis circle CBF volume, acceleration time (AT), pulsatile index (PI), and resistive index (RI).
    • Administered cognitive tests including Mini-Mental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA).
    • Compared 41 severe DAS patients, 41 moderate DAS patients, and 52 controls without DAS.

    Main Results:

    • Patients with DAS exhibited significantly lower mean CBF volume compared to controls.
    • Arterial stiffness markers (increased AT, RI, PI) were significantly higher in DAS groups versus controls.
    • No significant difference in MMSE or MoCA scores was observed based on CBF parameters or arterial stiffness.

    Conclusions:

    • Patients with DAS demonstrate reduced cerebral blood flow volume and increased arterial stiffness.
    • Cognitive impairment in DAS patients appears primarily associated with comorbidities rather than altered CBF parameters.
    Abstract

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