Vocal cord paralysis following lithium button battery ingestion in children

Qingchuan Duan1, Fengzhen Zhang1, Guixiang Wang1

  • 1Department of Otorhinolaryngology Head and Neck Surgery, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Insights

Prompt removal of esophageal button batteries in children is crucial to prevent severe complications like vocal cord paralysis. Early intervention with respiratory support and neurotrophic treatment may improve vocal cord function recovery.

Area of Science:

  • Pediatric Otolaryngology
  • Pediatric Gastroenterology
  • Emergency Medicine

Background:

  • Button battery ingestion in children poses significant health risks, particularly when the battery diameter exceeds 20 mm.
  • Esophageal button battery impaction can lead to severe complications including perforation, mediastinitis, tracheoesophageal fistula, vocal cord paralysis, and hemorrhage.

Purpose of the Study:

  • To investigate the occurrence and outcomes of vocal cord paralysis secondary to esophageal button battery ingestion in pediatric patients.
  • To assess the effectiveness of prompt removal and early supportive treatments for vocal cord paralysis in this population.

Main Methods:

  • Retrospective review of medical records of children treated for vocal cord paralysis and esophageal button battery ingestion between January 2016 and March 2020.
  • Analysis of patient demographics, battery type and size, time to removal, removal methods, and clinical outcomes including respiratory support and tracheotomy.

Main Results:

  • Five pediatric patients (9-58 months) with vocal cord paralysis due to 20-mm button battery ingestion were identified.
  • Four patients experienced bilateral vocal cord paralysis; one had unilateral paralysis. Three patients required tracheotomy, with two remaining dependent at follow-up.
  • One patient died from multiple organ dysfunction syndrome; two without tracheotomy are under close follow-up.

Conclusions:

  • Vocal cord paralysis serves as an early indicator of disease severity in pediatric button battery ingestion.
  • Prompt button battery removal is essential to mitigate severe complications.
  • Early neurotrophic and glucocorticoid therapy may aid vocal cord movement recovery, potentially avoiding tracheotomy.

Related Concept Videos

Depolarizing Blockers: Mechanism of Action01:28

Depolarizing Blockers: Mechanism of Action

Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
2.4K
Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
496
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
457
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
1.4K
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
292
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.1K