Related Experiment Video
Updated: Dec 6, 2025

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
[Diabetic foot attack. Pathophysiological description, clinical presentation, treatment and outcomes]
Gabriela V Carro1,2, Ruben Saurral1,3,4, Erica L Witman1,5
1Comité de Pie Diabético de la Sociedad Argentina de Diabetes (SAD), Buenos Aires, Argentina.
Diabetic foot attack requires urgent intervention to save limbs and lives. Recognizing classic, ischemic, and Charcot presentations ensures prompt treatment, preventing amputation.
Area of Science:
- Podiatry
- Diabetology
- Vascular Surgery
Background:
- Diabetic foot attack is a severe condition threatening limb and life.
- Urgent intervention is critical, emphasizing the "time is tissue" principle.
- It encompasses infected, ischemic, and Charcot neuroarthropathy presentations.
Purpose of the Study:
- To define and describe diabetic foot attack.
- To highlight the urgency and severity of these conditions.
- To promote rapid, effective treatment and prevent amputation.
Main Methods:
- Review of pathophysiology, clinical presentation, and treatment.
- Description of classic, ischemic, and atypical (Charcot) diabetic foot attacks.
- Emphasis on diagnostic confirmation and timely intervention.
Main Results:
- Diabetic foot attack includes severe infection with necrosis, critical ischemia, and acute Charcot neuroarthropathy.
- Prompt surgical debridement, antibiotics, or revascularization are key treatments.
- Accurate diagnosis and off-loading are crucial for Charcot foot.
Conclusions:
- Identifying diabetic foot attack subtypes guides urgent management.
- Timely and appropriate treatment is essential to avoid limb amputation.
- Understanding these presentations improves patient outcomes and limb salvage.
Related Concept Videos
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease IV: Nursing Management
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

