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Cholesterol Biosynthesis Influences Subtype Specificity and Plasticity in Pancreas Cancer
Sita Kugel1, Sunil R Hingorani2
1Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Cancer Cell
|October 13, 2020
Abstract:
Cellular plasticity contributes to intratumoral heterogeneity, metastatic spread, and treatment resistance of cancers. In this issue of Cancer Cell, Gabitova-Cornell et al. identify the potential to inadvertently develop an undifferentiated and more aggressive pancreas cancer with agents commonly prescribed to manage heart disease risk.
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