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Related Experiment Video

Updated: Dec 6, 2025

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
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Primary Spinal Intradural Extramedullary Mesenchymal Chondrosarcoma.

Ryu Saito1, Nobuo Senbokuya1, Takashi Yagi1

  • 1Department of Neurosurgery, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan.

World Neurosurgery
|October 13, 2020
PubMed
Summary

Mesenchymal chondrosarcoma (MCS) is a rare spinal tumor. This report details a case of primary spinal intradural extramedullary MCS mimicking meningioma, highlighting its rarity and potential for good prognosis with complete surgical removal.

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Area of Science:

  • Neurosurgery
  • Orthopedic Oncology
  • Spinal Cord Tumors

Background:

  • Mesenchymal chondrosarcoma (MCS) is an exceptionally rare bone and soft tissue tumor.
  • Primary spinal intradural extramedullary MCS represents a particularly rare subtype, with limited documented cases.
  • This condition can present with symptoms mimicking more common spinal tumors like meningioma.

Observation:

  • A 42-year-old female presented with paraplegia and Brown-Séquard syndrome.
  • MRI revealed a homogeneously enhancing intradural mass with a dural tail sign at T8.
  • CT identified calcification within the mass.
  • The tumor was surgically resected via T7-8 laminectomies.

Findings:

  • Histopathological diagnosis confirmed mesenchymal chondrosarcoma (MCS).
Keywords:
Mesenchymal chondrosarcomaSpinal tumorSurgical resection

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  • No metastatic lesions were detected by PET scan.
  • The patient experienced no recurrence during a 2-year follow-up without adjuvant therapy.

    • Implications:

    • Primary spinal intradural extramedullary MCS may have a favorable prognosis compared to MCS in other locations.
    • Complete surgical resection is crucial for favorable outcomes.
    • Adjuvant therapy should be considered for potential recurrence, even after successful initial resection.