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Related Experiment Videos

Nitrate tolerance. A relevant clinical problem?

J Parker

    Drugs
    |January 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Nitrate tolerance develops quickly in patients with angina, impacting treatment. Intermittent nitrate therapy may prevent this tolerance, though the exact mechanism remains unclear.

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    Area of Science:

    • Pharmacology
    • Cardiology
    • Clinical Therapeutics

    Background:

    • Nitrate tolerance, a rapid decrease in therapeutic effect during continuous nitrate administration, significantly complicates angina management.
    • While initially dismissed, haemodynamic tolerance to nitrates is now recognized as clinically important for patients with angina pectoris.

    Purpose of the Study:

    • To investigate the mechanism of nitrate tolerance.
    • To evaluate the effectiveness of intermittent nitrate therapy in preventing tolerance.

    Main Methods:

    • Experimental investigation in animals and humans.
    • Analysis of sulfhydryl group depletion, S-nitrosothiol, and cyclic guanosine monophosphate production.

    Main Results:

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  • The hypothesis linking nitrate tolerance to reduced sulfhydryl groups and subsequent decreased cyclic guanosine monophosphate production was not supported.
  • The precise mechanism underlying nitrate tolerance remains undetermined.

    • Conclusions:

    • Intermittent nitrate therapy strategies appear effective in mitigating or preventing the development of nitrate tolerance.
    • Further research is needed to elucidate the exact mechanism of nitrate tolerance.