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Association between nitrated lipoproteins and vascular function in type 2 diabetes
Ajibola Adedayo1, Ayobami Eluwole1, Fasika Tedla1
1State University of New York, Downstate Medical Center, Department of Medicine, 450 Clarkson Ave., Brooklyn, New York 11203, USA.
Frontiers in Bioscience (Landmark Edition)
|October 13, 2020
Summary
Nitrated HDL (NT-HDL) is linked to poorer microvascular function in type 2 diabetes patients. This finding suggests NT-HDL may help identify individuals at risk for early diabetic microvascular complications.
Area of Science:
- Cardiovascular Research
- Metabolic Disorders
- Biomarker Discovery
Background:
- Elevated nitrated lipoproteins (NT-HDL, NT-LDL) are implicated in coronary artery disease.
- Diabetic vascular dysfunction is a significant complication of type 2 diabetes mellitus (T2DM).
Purpose of the Study:
- To investigate the association between plasma NT-HDL and NT-LDL levels and vascular dysfunction in African-American patients with T2DM.
Main Methods:
- Quantified NT-HDL and NT-LDL using ELISA in 125 T2DM patients.
- Assessed microvascular function via vascular reactivity index (VRI).
- Measured large artery stiffness using carotid-femoral pulse wave velocity (PWV) and carotid intima-media thickness (CIMT).
Main Results:
- NT-HDL correlated with reduced VRI in the total population and in patients with HbA1c ≥ 7.0%.
- NT-LDL was associated with increased CIMT in the total population and in patients with HbA1c > 7.0%.
- Multivariable analysis confirmed NT-HDL as an independent predictor of VRI in the total and well-controlled T2DM groups.
Conclusions:
- Plasma NT-HDL may serve as a valuable biomarker for identifying T2DM patients at risk of developing early microvascular complications.
- These findings highlight the role of nitrated lipoproteins in the pathogenesis of diabetic vascular dysfunction.
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