Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

156
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
156
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

92
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
92
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

110
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
110
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

238
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
238
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

128
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
128
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

954
Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily...
954

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deep biochemical phenotyping reveals prognostic value of rare genetic variants in adult kidney stone disease.

The Journal of clinical investigation·2026
Same author

Signs of Premature Kidney Aging in Mice With Error-Prone Protein Synthesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2025
Same author

Estimating 24-hour urine phosphate excretion from spot urine.

Clinical kidney journal·2025
Same author

Updates on renal phosphate transport.

Current opinion in nephrology and hypertension·2025
Same author

Acid excretion is impaired in calcium oxalate stone formers.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2025
Same author

The calcium-sensing receptor has only a parathyroid hormone-dependent role in the acute response of renal phosphate transporters to phosphate intake.

American journal of physiology. Renal physiology·2024

Related Experiment Video

Updated: Dec 6, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.2K

Phosphate and Kidney Healthy Aging.

Isabel Rubio-Aliaga1

  • 1Institute of Physiology, University of Zurich, and the National Center for Competence in Research NCCR Kidney.CH, Zurich, Switzerland, isabel.rubioaliaga@uzh.ch.

Kidney & Blood Pressure Research
|October 13, 2020
PubMed
Summary
This summary is machine-generated.

High phosphate intake from processed foods may negatively impact healthy aging and kidney function. A balanced diet rich in natural phosphate sources can promote longevity and overall health.

Keywords:
AgingCardiovascular diseaseChronic kidney diseaseMortalityPhosphate

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.3K

Related Experiment Videos

Last Updated: Dec 6, 2025

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

2.2K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.3K

Area of Science:

  • Gerontology
  • Nephrology
  • Nutritional Science

Background:

  • The global population is aging, increasing the need to understand healthy aging and prevent multimorbidities.
  • Kidney function naturally declines with age, but the extent to which this is preventable remains unclear.
  • Chronic kidney disease (CKD) risk factors include aging, hypertension, diabetes, and obesity, with growing concerns about dietary phosphate intake.

Purpose of the Study:

  • To investigate the impact of chronic high phosphate consumption on healthy aging.
  • To explore the relationship between dietary phosphate, serum phosphate levels, and kidney health.
  • To assess the challenges in accurately measuring dietary phosphate intake, particularly from processed foods.

Main Methods:

  • Review of existing studies on phosphate metabolism and aging.
  • Analysis of the role of food additives and preservatives in phosphate consumption.
  • Discussion of methodologies for assessing dietary phosphate intake and their limitations.

Main Results:

  • Elevated serum phosphate levels are linked to increased mortality and cardiovascular disease risk.
  • Higher phosphate levels exacerbate CKD progression and may impair kidney function in healthy individuals.
  • Acute high phosphate intake can lead to acute kidney injury.

Conclusions:

  • Dietary phosphate, especially from processed foods, may pose a risk to healthy aging and kidney function.
  • Accurate assessment of phosphate intake is challenging, with dietary recalls often underestimating consumption.
  • A diet emphasizing natural food sources of phosphate may support healthy aging and longevity.