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Blood-Based Biomarkers Are Associated with Different Ischemic Stroke Mechanisms and Enable Rapid Classification

Dorin Harpaz1,2, Raymond C S Seet3, Robert S Marks2

  • 1School of Material Science & Engineering, Nanyang Technology University, 50 Nanyang Avenue, Singapore 639798, Singapore.

Diagnostics (Basel, Switzerland)
|October 14, 2020
PubMed

Insights

Blood biomarkers can help classify ischemic stroke causes faster than current methods. This review explores biomarkers for differentiating stroke mechanisms, aiding quicker therapeutic decisions.

Area of Science:

  • Neurology
  • Biochemistry
  • Biomarker Discovery

Background:

  • Stroke is a leading cause of death, with ischemic stroke accounting for 87% of cases.
  • Accurate subtyping of ischemic stroke is crucial for effective treatment but current methods are time-consuming.
  • Blood-based biomarkers offer a promising avenue for rapid and precise stroke mechanism classification.

Purpose of the Study:

  • To review recent studies on blood-based biomarkers for differentiating ischemic stroke mechanisms.
  • To discuss specific biomarkers and their potential cut-off values for classifying cardioembolic and atherosclerosis stroke.
  • To present the concept of a point-of-care biosensor for on-site biomarker measurement.

Main Methods:

  • Literature review of studies investigating blood-based biomarkers and ischemic stroke mechanisms.
  • Analysis of specific biomarkers including b-type natriuretic peptide, d-dimer, inflammatory markers, and lipid profiles.
  • Discussion of potential cut-off values for classification and a proposed biosensor device structure.

Main Results:

  • Various blood biomarkers show potential in differentiating between ischemic stroke subtypes.
  • Specific biomarkers like BNP, D-dimer, CRP, TNF-α, IL-6, IL-1β, NLR, cholesterol, triglycerides, HDL, LDL, and ApoA are discussed.
  • Potential cut-off values are identified for classifying cardioembolic and atherosclerosis stroke.

Conclusions:

  • Blood-based biomarkers can significantly improve the speed and accuracy of ischemic stroke classification.
  • The development of point-of-care biosensors could enable rapid, on-site diagnosis and treatment decisions.
  • Further research into these biomarkers and biosensor technology holds promise for enhancing stroke patient care.

Keywords:
blood-based biomarkersdiagnosticsetiology classificationischemic stroke mechanismspoint-of-care biosensorsstatistical analysis

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