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Bioaccessible Raspberry Extracts Enriched in Ellagitannins and Ellagic Acid Derivatives Have Anti-Neuroinflammatory
Gonçalo Garcia1,2,3, Teresa Faria Pais1,4, Paula Pinto2,5,6
1Instituto de Biologia Experimental e Tecnológica (iBET), apartado 12, 2781-901 Oeiras, Portugal.
Antioxidants (Basel, Switzerland)
|October 14, 2020
Summary
Dietary ellagitannins from raspberries show potent anti-inflammatory effects, reducing neuroinflammation markers. These compounds, unlike anthocyanins, offer promising neuroprotection against neurodegenerative disorders.
Area of Science:
- Neuroscience
- Nutritional Science
- Pharmacology
Background:
- Chronic neuroinflammation is linked to neurodegenerative diseases.
- Dietary polyphenols possess anti-inflammatory and neuroprotective properties.
- Raspberry genotypes vary in polyphenol profiles, offering a model for bioactivity assessment.
Purpose of the Study:
- To investigate the relationship between different polyphenol classes in raspberries and their anti-inflammatory bioactivity.
- To evaluate the neuroprotective potential of raspberry-derived polyphenol fractions on microglia.
Main Methods:
- Utilized five raspberry genotypes with distinct polyphenol profiles.
- Generated gastro-intestinal bio-accessible fractions simulating absorbed metabolites.
- Assessed anti-inflammatory potential in lipopolysaccharide (LPS)-stimulated microglia.
Main Results:
- A fraction rich in ellagitannins, their degradation products, and ellagic acid (genotype 2J19) significantly reduced pro-inflammatory markers (CD40, NO, TNF-α, superoxide).
- This ellagitannin-rich fraction modulated key inflammatory pathways (NF-κB, MAPK, NFAT).
- The fraction also enhanced the release of the anti-inflammatory cytokine IL-10, contrasting with anthocyanin-rich fractions.
Conclusions:
- Ellagitannins and their derivatives are key anti-inflammatory polyphenols in raspberries.
- These compounds show significant potential for alleviating neuroinflammation.
- Raspberry ellagitannins represent promising therapeutic agents for neurodegenerative disorders.
