Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bulimia Nervosa01:30

Bulimia Nervosa

520
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
520
Autoimmune Disorders01:29

Autoimmune Disorders

1.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
1.2K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

590
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
590
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors01:24

Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors

964
Peptic ulcer disease, commonly called PUD, represents a multifaceted condition characterized by disruptions in the lining of the gastrointestinal (GI)  tract. Central to the protection of the gastrointestinal lining is the mucosal-bicarbonate barrier. This physiological defense mechanism is a formidable shield against the corrosive effects of gastric acid and pepsin secretion in the stomach. Its role is pivotal in maintaining the structural integrity of the stomach's inner lining.
964
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.0K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

755
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
755

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hidradenitis suppurativa: epidemiology, diagnosis, molecular pathogenesis and therapy.

Molecular biomedicine·2026
Same author

Distinctive Reactivity to the C-terminal Epitope of BP180 Characterizes Immune Checkpoint Inhibitor-associated Bullous Pemphigoid, and an ELISA Based on the BP180 Ectodomain Enables Prompt Diagnosis in a Subset of Patients.

Acta dermato-venereologica·2026
Same author

Sequential Field Therapy in Actinic Keratosis: A Mechanism-Based Rationale for Complementary Treatment Strategies.

Journal of clinical medicine·2026
Same author

Line-field confocal optical coherence tomography for biopsy-site selection and treatment monitoring in plaque morphea.

Dermatology reports·2026
Same author

Skin Cancer Prevention and Antiaging: Role of Nicotinamide.

International journal of molecular sciences·2026
Same author

Non-Invasive Imaging in Diagnosis and Monitoring of Favre-Racouchot Disease.

International journal of dermatology·2026

Related Experiment Video

Updated: Dec 6, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.8K

Bullous Pemphigoid: Trigger and Predisposing Factors.

Francesco Moro, Luca Fania, Jo Linda Maria Sinagra1

  • 1IDI-IRCCS, via dei Monti di Creta 104, 00167 Rome, Italy.

Biomolecules
|October 14, 2020
PubMed
Summary

Bullous pemphigoid (BP), a blistering disease, is triggered by autoantibodies against BP180 and BP230. Identifying predisposing and trigger factors like genetics and infections aids understanding and improves prognosis.

Keywords:
autoimmune bullous diseasebullous pemphigoidetiopathogenesispredisposing factorstrigger factors

More Related Videos

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

774
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.4K

Related Experiment Videos

Last Updated: Dec 6, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.8K
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

774
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.4K

Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disease.
  • It is characterized by autoantibodies targeting hemidesmosomal proteins BP180 and BP230.
  • BP pathogenesis involves an interplay of genetic predisposition, comorbidities, aging, and external triggers.

Purpose of the Study:

  • To elucidate the role of predisposing and trigger factors in bullous pemphigoid pathogenesis.
  • To enhance the understanding of the complex etiology of BP.
  • To highlight the clinical significance of identifying trigger factors for improved patient outcomes.

Main Methods:

  • Review of existing literature on bullous pemphigoid.
  • Analysis of predisposing factors including human leukocyte antigen (HLA) genes.
  • Identification and categorization of various trigger factors associated with BP onset or exacerbation.

Main Results:

  • Autoantibodies against BP180 and BP230 are central to BP development.
  • Genetic factors (e.g., HLA), aging, and comorbidities are significant predisposing elements.
  • Diverse triggers, including drugs, infections, trauma, and radiation, can initiate or worsen BP.

Conclusions:

  • Understanding the interaction of predisposing and trigger factors is crucial for unraveling BP pathogenesis.
  • Accurate patient history focusing on potential triggers can lead to timely intervention.
  • Prompt removal of identified trigger factors may improve the prognosis of bullous pemphigoid.