Related Experiment Video
Updated: Dec 6, 2025
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Antibody-Targeted Imaging of Gastric Cancer
Komal Mandleywala1, Shayla Shmuel1, Patricia M R Pereira1
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Abstract:
The specificity of antibodies for antigens overexpressed or uniquely expressed in tumor cells makes them ideal candidates in the development of bioconjugates for tumor imaging. Molecular imaging can aid clinicians in the diagnosis of gastric tumors and in selecting patients for therapies targeting receptors with a heterogeneous intratumoral or intertumoral expression. Antibodies labeled with an imaging radiometal can be used to detect primary tumors and metastases using whole-body positron emission tomography (PET) or single photon emission computed tomography (SPECT), both during diagnosis and monitoring disease response. Conjugated with fluorescent dyes, antibodies can image tumors by targeted optical imaging. This review provides an overview of the most recent advances in the use of antibodies labeled with radiometals or conjugated with fluorescent dyes for gastric cancer imaging.
Insights
Antibodies targeting cancer antigens offer precise tumor imaging for gastric cancer diagnosis and treatment selection. This review highlights advances in radiometal-labeled and fluorescently conjugated antibodies for molecular imaging.
Area of Science:
- Oncology
- Molecular Imaging
- Immunology
Background:
- Antibodies' specific binding to tumor-associated antigens makes them valuable for targeted cancer therapies and diagnostics.
- Molecular imaging techniques like PET and SPECT are crucial for diagnosing gastric tumors and assessing receptor expression heterogeneity.
- Accurate imaging aids in patient selection for targeted therapies and monitoring treatment response.
Purpose of the Study:
- To review recent advancements in antibody-based molecular imaging for gastric cancer.
- To discuss the application of radiometal-labeled and fluorescently conjugated antibodies in gastric cancer detection and management.
Main Methods:
- Review of current literature on antibody-based imaging agents for gastric cancer.
- Analysis of techniques utilizing radiometals for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT).
- Evaluation of fluorescent dye conjugation for targeted optical imaging.
Main Results:
- Antibodies labeled with imaging radiometals enable whole-body detection of primary gastric tumors and metastases.
- Fluorescently conjugated antibodies facilitate targeted optical imaging of tumors.
- These imaging modalities aid in diagnosis, patient stratification, and monitoring therapeutic efficacy.
Conclusions:
- Antibody-based molecular imaging represents a significant advancement in gastric cancer diagnostics.
- Targeted imaging agents improve the precision of tumor detection and characterization.
- Future research will likely focus on further refining these antibody-based strategies for personalized gastric cancer care.
