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Emerging Roles of Single-Cell Multi-Omics in Studying Developmental Temporal Patterning.

Andrea Lopes1, Elia Magrinelli1, Ludovic Telley1

  • 1Department of Basic Neuroscience, University of Lausanne, 1005 Lausanne, Switzerland.

International Journal of Molecular Sciences
|October 14, 2020
PubMed
Summary

Temporal patterning in neurogenesis is crucial for brain development, involving cell-intrinsic and environmental factors. Recent single-cell technologies and multi-omics approaches offer new insights into this complex process.

Keywords:
bioinformaticscentral nervous systemdevelopmentextrinsicintrinsicneural progenitorsneuronomicstemporal patterning

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Brain complexity arises from precise spatial and temporal regulation during development.
  • Neurogenesis involves generating diverse cell types from progenitor cells in both vertebrates and invertebrates.
  • Temporal patterning of neuronal progenitors relies on intricate cell-intrinsic and cell-extrinsic mechanisms.

Purpose of the Study:

  • To provide an overview of recent advances in temporal patterning research in *Drosophila* and vertebrates.
  • To highlight the roles of cell-intrinsic mechanisms and environmental influences.
  • To discuss the contribution of multi-omics approaches and future perspectives.

Main Methods:

  • Review of recent high-throughput single-cell technologies.
  • Analysis of computational methods for biological data.
  • Integration of multi-omics data (genomics, transcriptomics, etc.).

Main Results:

  • Single-cell technologies and computational analysis have yielded significant insights into temporal patterning.
  • Both intrinsic cellular programs and extrinsic environmental cues regulate progenitor temporal dynamics.
  • Multi-omics approaches have been instrumental in advancing current understanding.

Conclusions:

  • Temporal patterning is a fundamental process in central nervous system (CNS) development.
  • Future research utilizing advanced -omics techniques promises deeper understanding of temporal patterning.
  • Integrated approaches are key to deciphering the complexity of neuronal progenitor regulation.