Related Experiment Video

Updated: Dec 6, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.8K

[CME: Left Bundle Branch Block and Painful Left Bundle Branch Block Syndrome]

Luca Oechslin1, Daniel Hofer1, Matthias Hermann1

  • 1Klinik für Kardiologie, Universitätsspital Zürich.

Praxis
|October 14, 2020
PubMed

Insights

Left bundle branch block (LBBB) indicates abnormal heart electrical signals, leading to inefficient contractions and increased mortality risk. Cardiac resynchronization therapy (CRT) offers a specific treatment for LBBB, while painful LBBB can occur in healthy hearts.

Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Left bundle branch block (LBBB) signifies aberrant myocardial electrical signal transmission.
  • LBBB causes asynchronous left ventricular activation, impairing cardiac contraction efficiency.
  • It is frequently associated with underlying heart disease and is an independent predictor of cardiovascular mortality.

Purpose of the Study:

  • To review the implications of left bundle branch block.
  • To discuss diagnostic and therapeutic strategies for LBBB.
  • To address the less common presentation of painful LBBB in structurally normal hearts.

Main Methods:

  • Review of electrocardiographic findings related to LBBB.
  • Discussion of underlying etiologies and risk stratification.
  • Overview of current therapeutic options, including cardiac resynchronization therapy (CRT).

Main Results:

  • LBBB is a marker for significant cardiac pathology and mortality risk.
  • Cardiac resynchronization therapy (CRT) provides a targeted treatment for specific LBBB cases.
  • Painful LBBB can manifest in individuals without apparent structural heart disease.

Conclusions:

  • Prompt evaluation of LBBB is crucial due to its association with cardiovascular mortality.
  • CRT represents a significant advancement in LBBB management.
  • The syndrome of painful LBBB warrants further investigation, particularly in the absence of structural heart disease.

Keywords:
Angina pectorisErgometrieLeft bundle branch blockLinksschenkelblockasynchronous ventricular contractiondyssynchrone Kontraktionpainful left bundle branch block

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