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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
Prevalence of methicillin-resistant coagulase-negative staphylococci among Egyptian patients after surgical
Eman F Ahmed1,2, Gamal Fm Gad2, Wafaa E Soliman3,4
1Assistant professor, Microbiology and Immunology Department, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Abstract:
Coagulase-negative staphylococci (CoNS) are frequently isolated from wound infections. There are limited data examining the prevalence of methicillin-resistant CoNS (MRCoNS) among Egyptian patients after surgery. Thus, we studied 208 hospitalised patients, who had skin and soft tissue infections (SSTIs) due to various causes. Samples were cultured for isolation and identification of CoNS and isolates were screened for susceptibility against 23 different antimicrobials. Out of 241 Staphylococcal isolates, 114 (47.3%) were CoNS. The prevalence of MRCoNS among surgical site infection, diabetic foot, abscess, and burn patients was 13.4%, 11.5%, 15.6%, and 10.3%, respectively. The lowest resistance of the 27 identified MRCoNS isolates was to vancomycin, amikacin and gatifloxacin (7% each). We conclude that CoNS isolates are major pathogens associated with wound infections at our institution and MRCoNS probably poses a substantial threat for patients in Egypt, though most MRCoNS isolates demonstrated susceptibility to vancomycin.
Insights
Coagulase-negative staphylococci (CoNS) are common in wound infections. Methicillin-resistant CoNS (MRCoNS) pose a significant threat to Egyptian patients, though many remain susceptible to vancomycin.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Science
Background:
- Coagulase-negative staphylococci (CoNS) are frequently implicated in wound infections.
- Limited data exist on the prevalence of methicillin-resistant CoNS (MRCoNS) in Egyptian surgical patients.
- Skin and soft tissue infections (SSTIs) represent a significant clinical challenge.
Purpose of the Study:
- To determine the prevalence of MRCoNS in hospitalized Egyptian patients with SSTIs.
- To identify antimicrobial susceptibility patterns of isolated CoNS and MRCoNS.
- To assess the threat posed by MRCoNS in this patient population.
Main Methods:
- Cultured and identified 114 CoNS from 241 staphylococcal isolates from 208 hospitalized patients with SSTIs.
- Screened CoNS isolates for methicillin resistance.
- Tested susceptibility of MRCoNS isolates against 23 different antimicrobials.
Main Results:
- CoNS constituted 47.3% of staphylococcal isolates.
- MRCoNS prevalence varied: 13.4% in surgical site infections, 11.5% in diabetic foot infections, 15.6% in abscesses, and 10.3% in burn patients.
- The 27 identified MRCoNS isolates showed lowest resistance (7%) to vancomycin, amikacin, and gatifloxacin.
Conclusions:
- CoNS are major pathogens in wound infections at the study institution.
- MRCoNS represent a substantial threat to Egyptian patients, particularly those with SSTIs.
- Most identified MRCoNS isolates remained susceptible to vancomycin, indicating its potential therapeutic value.
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