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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis III01:31

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Introduction to Connective Tissues01:11

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Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Tuberculosis heralding connective tissue disorder.

U Pratap1, M Ravindrachari2, A RamyaPriya3

  • 1Assistant Professor, Department of Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India.

Tropical Doctor
|October 14, 2020
PubMed
Summary

Tuberculosis can cause organizing pneumonia, sometimes before connective tissue disease is apparent. Investigating Mycobacterium tuberculosis is crucial for early diagnosis and treatment with anti-tuberculosis therapy alone.

Keywords:
Mycobacterium tuberculosisOrganising pneumoniaoverlap syndromepolymyositissystemic sclerosis

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Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Rheumatology

Background:

  • Organizing pneumonia can stem from connective tissue diseases and infections.
  • Rarely, organizing pneumonia precedes overt connective tissue disease.
  • Mycobacterium tuberculosis is an uncommon cause of organizing pneumonia.

Observation:

  • A 50-year-old male smoker with diabetes presented with constitutional symptoms and respiratory distress.
  • Chest imaging revealed consolidation with halo signs.
  • Serological tests indicated an overlap of systemic sclerosis and polymyositis.

Findings:

  • Lung biopsy confirmed organizing pneumonia.
  • Bronchoalveolar lavage identified Mycobacterium tuberculosis.
  • The patient had an unestablished connective tissue disease with concurrent tuberculosis.

Implications:

  • Mycobacterium tuberculosis should be considered in organizing pneumonia cases, especially with atypical presentations.
  • This diagnosis is vital in patients with subclinical connective tissue diseases.
  • Effective treatment with anti-tuberculosis therapy alone is possible, potentially avoiding systemic steroids.