Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery
A A Rosenkranz1,2, T A Slastnikova2
1Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia. aar@igb.ac.ru.
Biochemistry. Biokhimiia
|October 14, 2020
Summary
Epidermal growth factor receptor (EGFR) is crucial in cancer development. This review explores novel therapies targeting EGFR overexpression, including targeted delivery and gene therapy, to improve cancer treatment outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Epidermal growth factor receptor (EGFR) is a cell surface protein involved in growth factor signaling.
- EGFR overexpression and mutations are common in various cancers, driving tumor growth.
- Targeted therapies blocking EGFR activation represent a key advance in personalized medicine.
Purpose of the Study:
- To review current understanding of EGFR structure, function, and signaling in cancer.
- To analyze therapeutic strategies targeting EGFR overexpression and its signaling pathway.
- To discuss novel approaches for targeted drug delivery and gene therapy for EGFR-driven cancers.
Main Methods:
- Comprehensive literature review of EGFR biology and therapeutic interventions.
- Analysis of signaling cascades, intracellular transport, and expression patterns of EGFR.
- Evaluation of targeted delivery systems, including chemotherapeutics, radionuclides, immunotoxins, and photosensitizers.
Main Results:
- EGFR plays a significant role in multiple cancer types, making it a key therapeutic target.
- Various agents and strategies are being developed to block EGFR signaling and exploit its overexpression.
- Multifunctional systems and receptor-mediated endocytosis show promise for enhanced cancer cell targeting.
Conclusions:
- Despite successes, EGFR-targeted therapies face challenges, necessitating innovative treatment approaches.
- Targeted delivery systems and gene therapy offer potential for overcoming treatment resistance.
- Further research into multifunctional systems and EGFR-mediated endocytosis could lead to improved cancer therapies.
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