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COVID-19 and Type 2 Diabetes Mellitus: HCQ may be the Holy Grail

Rimesh Pal1, Manoj K Bhasin2, Sanjay K Bhadada1

  • 1Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Infectious Disorders Drug Targets
|October 14, 2020
PubMed

Insights

Hydroxychloroquine (HCQ) shows potential as a third-line anti-diabetic agent for Type 2 Diabetes Mellitus (T2DM) patients, especially during the COVID-19 pandemic. Its use requires careful consideration of contraindications and existing therapies.

Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Pharmacology

Background:

  • COVID-19 poses a significant global health threat, with higher mortality in diabetic patients.
  • No definitive vaccine or therapy currently exists for COVID-19.
  • Hydroxychloroquine (HCQ) is being explored for COVID-19 treatment and prophylaxis.

Purpose of the Study:

  • To evaluate the potential of HCQ as an anti-diabetic agent in Type 2 Diabetes Mellitus (T2DM).
  • To consider HCQ's role in T2DM management amidst the COVID-19 pandemic.

Main Methods:

  • Review of existing clinical data on HCQ use in COVID-19 and T2DM.
  • Analysis of HCQ's pharmacological properties as an anti-diabetic drug.
  • Assessment of HCQ's safety profile and contraindications.

Main Results:

  • HCQ is approved in India as an adjunct therapy for T2DM patients on metformin and sulfonylurea.
  • Limited clinical data supports HCQ's use in COVID-19.
  • Indiscriminate HCQ use carries risks.

Conclusions:

  • HCQ may be considered a third-line add-on anti-diabetic agent for T2DM patients.
  • Use of HCQ should only occur after contraindications are ruled out.
  • This consideration is particularly relevant during the COVID-19 pandemic.

Keywords:
COVID-19HCQSARS-CoV-2.T2DMdiabetes mellituspandemicvaccine

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