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Troponin T but not C reactive protein is associated with future surgery for aortic stenosis: a population-based

Anders Holmgren1, Johan Ljungberg2, Johan Hultdin3

  • 1Public Health and Clinical Medicine, Cardiac Surgery, Umeå University, Umeå, Sweden.

Open Heart
|October 14, 2020
PubMed

Insights

High-sensitivity troponin T (hs-TnT) is linked to a higher risk and earlier need for aortic stenosis (AS) surgery. Hs-TnT also correlates with increased myocardial mass, suggesting its potential as a biomarker for intervention timing.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Aortic Stenosis

Background:

  • Aortic stenosis (AS) is a significant cardiovascular condition.
  • Prognostic markers are crucial for managing AS patients.
  • High-sensitivity troponin T (hs-TnT) and high-sensitivity C-reactive protein (hs-CRP) are potential biomarkers.

Purpose of the Study:

  • To investigate the association of hs-TnT and hs-CRP with myocardial mass in AS patients.
  • To evaluate the predictive value of hs-TnT and hs-CRP for future AS surgery.
  • To determine if these biomarkers can indicate the need for intervention.

Main Methods:

  • Retrospective analysis of 336 AS patients who underwent surgery.
  • Assessment of preoperative myocardial mass and coronary artery disease (CAD).
  • Measurement of hs-TnT and hs-CRP from stored plasma samples.
  • Conditional logistic regression and survival analyses (Kaplan-Meier, Cox regression).

Main Results:

  • Hs-TnT was independently associated with a higher risk of AS surgery (OR 1.24, 95% CI 1.06-1.44).
  • Elevated hs-TnT levels correlated with a shorter time to surgery and increased myocardial mass.
  • Hs-CRP showed no significant association with AS surgery risk, time to surgery, or myocardial mass.

Conclusions:

  • Hs-TnT, but not hs-CRP, predicts increased risk and earlier need for AS surgery.
  • Hs-TnT's association with myocardial mass suggests its utility as a biomarker for intervention timing in AS.
Abstract

Keywords:
aortic valve diseaseepidemiologyrisk factorssurgery-valve

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