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Updated: Dec 6, 2025
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Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
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Cellular model systems to study cardiovascular injury from chemotherapy
Hananeh Fonoudi1,2, Paul W Burridge3,4
1Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Journal of Thrombosis and Thrombolysis
|October 14, 2020
Summary
Cardiotoxicity from cancer drugs is a major concern. Human induced pluripotent stem cells (hiPSCs) offer promising cell models for preclinical drug screening to ensure cardiovascular safety in cancer survivors.
Area of Science:
- Cardiovascular Research
- Stem Cell Biology
- Pharmacology
Background:
- Cancer therapies often cause cardiotoxicity, impacting cancer survivor health.
- Current preclinical drug safety screenings lack accuracy and reliability.
- Cardiovascular side effects necessitate improved methods for drug evaluation.
Purpose of the Study:
- To review in vivo and in vitro preclinical drug safety screenings.
- To highlight the application of hiPSC-derived cells in cardiotoxicity assays.
- To discuss cardiac organoids as advanced platforms for drug safety testing.
Main Methods:
- Overview of existing preclinical drug safety screening methods.
- Focus on human induced pluripotent stem cells (hiPSCs) derived cardiomyocytes, endothelial, and vascular smooth muscle cells.
- Exploration of unicellular assays and multi-cellular cardiac organoids.
Main Results:
- hiPSC-derived cells provide a scalable source of relevant cardiovascular cells.
- These cells enable measurement of drug-induced alterations in cardiac electrophysiology, contractility, and structure.
- Cardiac organoids offer a multi-cellular platform for comprehensive cardiotoxicity assessment.
Conclusions:
- hiPSC-derived cells are valuable tools for preclinical cardiotoxicity screening.
- Advanced cell models like cardiac organoids improve the accuracy of drug safety evaluations.
- These approaches are crucial for developing safer cancer therapies and improving survivor outcomes.
