Related Experiment Video
Updated: Jun 12, 2026

Manual Restraint and Common Compound Administration Routes in Mice and Rats
Published on: September 26, 2012
Injecting drug use, the skin and vasculature
Roy Robertson1, Barbara Broers2, Magdalena Harris3
1Centre for Population Health Sciences, Usher Institute, University of Edinburgh Old Medical School, Edinburgh, UK.
Injecting drug use commonly causes skin, soft tissue, and vascular damage due to unsafe practices and contaminated substances. This review covers the epidemiology, clinical aspects, and prevention of these injection-related harms.
Area of Science:
- Public Health
- Dermatology
- Vascular Medicine
Background:
- Injecting drug use is linked to significant skin, subcutaneous tissue, and blood vessel damage.
- Literature is expanding on new drugs, contaminants, and unsafe injection practices causing harm.
- Clinical issues range from localized trauma and infections to systemic blood infections and vascular disease.
Purpose of the Study:
- To review the epidemiology and causation of injecting-related skin, soft tissue, and vascular damage.
- To discuss clinical examination, investigation, and treatment modalities.
- To highlight prevention strategies for these health harms.
Main Methods:
- Literature review focusing on injecting-related health harms.
- Analysis of epidemiological data and causative factors.
- Synthesis of clinical findings, treatment options, and prevention approaches.
Main Results:
- Injection-related harms are multifactorial, involving equipment access, technique, drug purity, and environmental factors.
- A spectrum of clinical presentations exists, from minor trauma to severe systemic complications.
- Prevention requires addressing drug use, promoting sterile equipment, and improving injection techniques.
Conclusions:
- Injection-related skin, soft tissue, and vascular damage represent a significant public health concern.
- Comprehensive strategies are needed for prevention, including harm reduction and improved healthcare access.
- Further research into novel contaminants and tailored interventions is warranted.
Related Concept Videos
Additional Routes of Drug Administration
Administering drugs via inhalation allows for the direct delivery of gaseous, volatile substances or droplets to different parts of the respiratory tract. One of the advantages of the inhalation route is the rapid absorption of drugs into the circulatory system, which is possible because of the large surface area of...
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Routes of Drug Administration: Overview
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Non-Oral Extravascular Drug Absorption Routes
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more effectively...

