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Updated: Dec 6, 2025

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Glycogen synthase kinase-3β: a promising candidate in the fight against fibrosis

Hanxue Zheng1,2,3, Zhi Yang3, Zhenlong Xin3

  • 1Lab of Tissue Engineering, Faculty of Life Sciences, Northwest University, 229 TaiBai North Road, Xi'an 710069, China.

Theranostics
|October 14, 2020
PubMed

Insights

Glycogen synthase kinase-3β (GSK-3β) shows promise in combating fibrosis by inhibiting extracellular matrix accumulation and epithelial-mesenchymal transition. This review explores GSK-3β's role in fibrogenesis, highlighting its potential as a therapeutic target.

Area of Science:

  • Biomedical research
  • Cellular biology
  • Pathology

Background:

  • Fibrosis is a significant factor in disease progression and aging, with no current effective treatments.
  • Fibrogenesis, the process of fibrosis, impacts nearly all human organs and tissues.
  • Glycogen synthase kinase-3β (GSK-3β) is a key signaling mediator in various biological processes.

Purpose of the Study:

  • To review the role of GSK-3β in regulating fibrosis across different organs.
  • To identify upstream regulators and downstream effectors of the GSK-3β pathway in fibrosis.
  • To explore the potential of GSK-3β as a novel therapeutic target for fibrotic diseases.

Main Methods:

  • Literature review and synthesis of existing research on GSK-3β and fibrosis.
  • Analysis of GSK-3β's involvement in extracellular matrix accumulation.
  • Examination of GSK-3β's influence on epithelial-mesenchymal transition (EMT).

Main Results:

  • GSK-3β inhibits extracellular matrix (ECM) accumulation and epithelial-mesenchymal transition (EMT).
  • GSK-3β demonstrates protective effects against fibrosis in the heart, lung, liver, and kidney.
  • The study outlines upstream regulators and downstream effectors of GSK-3β in fibrotic pathways.

Conclusions:

  • GSK-3β plays a crucial protective role in mitigating fibrosis.
  • Understanding the GSK-3β pathway offers potential therapeutic strategies for fibrotic conditions.
  • GSK-3β represents a promising novel target for future anti-fibrotic therapies.
Keywords:
AgingEpithelial-mesenchymal transitionFibrosisGlycogen synthase kinase-3βSignaling pathway

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