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Synthetic Cannabinoids and Its Association With Persistent Negative Symptoms of Schizophrenia
Ritvij Satodiya1, Nikhil Palekar2
1Child and Adolescent Psychiatry, New York University Grossman School of Medicine, New York, USA.
Abstract:
Schizophrenia has a multidomain symptom cluster, including positive, negative, and cognitive symptoms. Synthetic cannabinoids (SC) commonly perpetuate the positive symptoms of schizophrenia. We present a case of predominant negative symptoms following the use of SC even though our patient had a consistent history of experiencing positive symptoms in the past. The hypoactive dopaminergic system in the prefrontal cortex can induce negative symptoms in schizophrenia. However, the modulating properties of SC on cannabinoid receptors can feed into the negative symptom progression. The psychoactive properties of SC need further research to understand its clinical characteristics.
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