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Collapsing glomerulopathy in a patient with mixed connective tissue disease
Gajapathiraju Chamarthi1, William L Clapp1, Saraswathi Gopal2
1Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610, USA.
Collapsing glomerulopathy, a kidney disease, was diagnosed in a patient with mixed connective tissue disease. Steroid treatment stabilized her kidney function and reduced proteinuria, suggesting a potential therapy.
Area of Science:
- Nephrology
- Rheumatology
- Pathology
Background:
- Collapsing glomerulopathy (CG) is a severe podocytopathy with diverse causes.
- Mixed connective tissue disease (MCTD) is an autoimmune disorder with overlapping features of other connective tissue diseases.
- Previous reports have anecdotally linked CG and MCTD.
Observation:
- A 53-year-old female presented with acute kidney injury and proteinuria.
- Renal biopsy confirmed collapsing glomerulopathy.
- Subsequent evaluation revealed a diagnosis of MCTD based on clinical presentation and serology.
Findings:
- The patient was treated with prednisone.
- Prednisone therapy led to stabilization of renal function.
- Proteinuria significantly reduced, and the patient achieved remission.
Implications:
- This case highlights a potential association between collapsing glomerulopathy and MCTD.
- Corticosteroids may be an effective first-line treatment for CG in the context of MCTD.
- Further research is warranted to explore this association and treatment strategy.
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