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Related Experiment Video

Updated: Dec 5, 2025

Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography
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Determining Gender-Based Differences in Retinal and Choroidal Thickness in Underweight Individuals via Swept-Source Optical Coherence Tomography

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Physiological changes in retinal layers thicknesses measured with swept source optical coherence tomography.

Elisa Viladés1,2, Amaya Pérez-Del Palomar2,3, José Cegoñino2,3

  • 1Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain.

Plos One
|October 14, 2020
PubMed
Summary

Age-related thinning affects most retinal layers, with significant changes observed between ages 35-64. The Retinal Nerve Fiber Layer (RNFL) thickens until the third decade before thinning.

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Area of Science:

  • Ophthalmology
  • Gerontology
  • Medical Imaging

Background:

  • Aging leads to physiological changes in ocular structures.
  • Understanding age-related retinal layer thickness is crucial for diagnosing eye diseases.

Purpose of the Study:

  • To evaluate age-related physiological changes in macular and peripapillary retinal layer thickness in healthy eyes.
  • To establish normative data for retinal layer thickness across different age groups.

Main Methods:

  • Employed Spectral-Domain Optical Coherence Tomography (SD-OCT) with a wide-field protocol (12x9 cm).
  • Measured thickness of Retina, Retinal Nerve Fiber Layer (RNFL), Ganglion Cell Layer (GCL+), GCL++, and choroid in 463 healthy eyes.
  • Compared mean layer thickness across four age groups: 20-34, 35-49, 50-64, and 65-79 years.

Main Results:

  • Significant thinning of most retinal layers occurred between the 35-49 and 50-64 age groups, particularly in the temporal superior quadrant.
  • RNFL and choroid layers showed significant thinning in specific quadrants and halves during this transition.
  • A notable thickening of RNFL in the temporal superior quadrant and choroid in the nasal half was observed when comparing the 20-34 and 35-49 age groups.

Conclusions:

  • Except for the RNFL, which shows thickening until the third decade, retinal layers exhibit progressive physiological thinning with age.
  • These findings highlight age-specific normative values for retinal layer thickness.
  • The study provides insights into the structural changes in the aging retina.