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A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

Nazar Mashtalir1, Hiroshi Suzuki2, Daniel P Farrell3

  • 1Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Cell
|October 14, 2020
PubMed
Summary

Researchers reveal the structure of the human BAF complex bound to nucleosomes, detailing how it remodels chromatin. This structural insight into the BAF complex (BRG1/BRM-associated factor) aids understanding of its role in health and disease.

Keywords:
ATP-dependent chromatin remodelingBAF complexcancercross-linking mass spectrometrycryoelectron microscopyhomology modelingmammalian SWI/SNF complexesmutations

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