Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

2.5K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.5K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.5K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.5K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

802
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
802
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

985
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
985
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

2.9K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
2.9K
Peripherally and Centrally Acting Muscle Relaxants: A Comparison01:09

Peripherally and Centrally Acting Muscle Relaxants: A Comparison

4.2K
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
4.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Driving impairment in patients with movement disorders: examining the Baylor driving questionnaire by objective driving assessment.

Clinical parkinsonism & related disorders·2026
Same author

Mouth Motor Overflow in Parkinson's Disease.

Movement disorders clinical practice·2026
Same author

The effects of EXOPULSE Mollii Suit in patients with fibromyalgia: a double-blind randomized sham-controlled trial (EXOFIB2).

Pain medicine (Malden, Mass.)·2026
Same author

Efficacy and safety of ocrelizumab in pediatric multiple sclerosis.

Multiple sclerosis and related disorders·2025
Same author

Spinocerebellar Ataxia Type 34: <i>ELOVL4</i> Recurrent Mutation in a Different Family.

Journal of clinical neurology (Seoul, Korea)·2025
Same author

The effect of the EXOPULSE Mollii suit on motor functions in patients with multiple sclerosis - a randomized sham-controlled crossover trial.

Multiple sclerosis journal - experimental, translational and clinical·2025

Related Experiment Video

Updated: Dec 5, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.5K

Tremor in Multiple Sclerosis-An Overview and Future Perspectives.

Karim Makhoul1,2, Rechdi Ahdab1,2,3, Naji Riachi1,2

  • 1Neurology Division, Lebanese American University Medical Center Rizk Hospital, Beirut 113288, Lebanon.

Brain Sciences
|October 15, 2020
PubMed
Summary

Multiple sclerosis (MS) tremor affects 25-58% of patients, significantly impacting quality of life. This review covers MS tremor

Keywords:
basal gangliacerebello-thalamo-cortical pathwayscerebellummovement disordermultiple sclerosispseudo-tremorthalamustremor

More Related Videos

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

27.3K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.5K

Related Experiment Videos

Last Updated: Dec 5, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

14.5K
Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System
12:19

Utilizing Transcranial Magnetic Stimulation to Study the Human Neuromuscular System

Published on: January 20, 2012

27.3K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.5K

Area of Science:

  • Neurology
  • Clinical Neuroscience

Background:

  • Tremor is a prevalent and debilitating symptom in multiple sclerosis (MS), historically recognized as a core feature.
  • It significantly diminishes patients' quality of life.

Purpose of the Study:

  • To provide a comprehensive overview of tremor in MS.
  • To discuss its epidemiology, clinical features, pathophysiology, assessment, and treatment options.
  • To suggest future research directions for unmet needs.

Main Methods:

  • Literature review and synthesis of existing research on MS tremor.
  • Analysis of epidemiological data, clinical presentations, and proposed pathophysiological mechanisms.
  • Evaluation of current and emerging assessment tools and therapeutic strategies.

Main Results:

  • MS tremor prevalence ranges from 25% to 58%.
  • Characterized by large amplitude, 2.5-7 Hz postural or intention tremor, potentially linked to cerebellar dysfunction.
  • Treatment options include medications, botulinum toxin, deep brain stimulation, and thalamotomy for severe cases.

Conclusions:

  • Understanding MS tremor's multifaceted nature is crucial for effective management.
  • Further research is needed to address diagnostic and therapeutic challenges.
  • Future studies should focus on refining assessment tools and developing targeted therapies for MS-related tremor.