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ADAMTS8 Inhibits Progression of Esophageal Squamous Cell Carcinoma

Zhonglin Wu1, Yanjun Shi2, Shuguang Ren3

  • 1Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.

DNA and Cell Biology
|October 15, 2020
PubMed

Insights

ADAMTS8 expression is reduced in esophageal squamous cell carcinoma (ESCC). Its restoration inhibits ESCC cell proliferation and invasion, offering a potential therapeutic target for this cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Disintegrins and metalloproteinases with thrombospondin motifs (ADAMTSs) are implicated in cancer development.
  • ADAMTS8 dysregulation is observed in various cancers, suggesting a role in carcinogenesis.

Purpose of the Study:

  • To investigate the role of ADAMTS8 in esophageal squamous cell carcinoma (ESCC).
  • To evaluate ADAMTS8 as a potential therapeutic target for ESCC.

Main Methods:

  • Quantitative analysis of ADAMTS8 expression in ESCC tissues versus non-tumor tissues.
  • In vitro functional assays assessing cell proliferation, migration, invasion, and apoptosis upon ADAMTS8 overexpression.
  • In vivo studies using mouse models to evaluate tumor growth with altered ADAMTS8 expression.

Main Results:

  • ADAMTS8 expression was significantly downregulated in ESCC tissues.
  • ADAMTS8 expression levels correlated with clinical stage and lymph node metastasis.
  • Overexpression of ADAMTS8 suppressed ESCC cell proliferation, migration, and invasion, while promoting apoptosis.
  • ADAMTS8 overexpression modulated levels of monocyte chemotactic protein-1 and interleukin-6.
  • In vivo studies confirmed that ADAMTS8 overexpression reduced tumor growth.

Conclusions:

  • ADAMTS8 functions as a tumor suppressor in ESCC.
  • Altering ADAMTS8 expression impacts ESCC cell behavior and tumor progression.
  • ADAMTS8 is a promising therapeutic target for managing esophageal squamous cell carcinoma.
Keywords:
ADAMTS8IL-6MCP-1esophageal squamous cell carcinoma (ESCC)invasionproliferation

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