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RELATIONSHIP BETWEEN INTERLEUKIN-6 GENE POLYMORPHISM AND HEART FAILURE IN PATIENTS WITH CORONARY ARTERY DISEASE AND

Pavlo G Kravchun1, Olga I Kadykova1, Natalia G Ryndina1

  • 1KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|October 15, 2020
PubMed

Insights

The -174G>C polymorphism in the interleukin-6 gene is linked to a higher risk of heart failure in patients with both coronary artery disease and obesity. This genetic variation impacts heart failure development in this patient group.

Area of Science:

  • Genetics and Cardiovascular Medicine
  • Molecular Biology and Disease Pathogenesis

Background:

  • Coronary artery disease (CAD) and obesity are significant risk factors for heart failure (HF).
  • Interleukin-6 (IL-6) is a pro-inflammatory cytokine implicated in cardiovascular disease progression.

Purpose of the Study:

  • To investigate the association between specific polymorphisms in the IL-6 gene promoter and the incidence of HF.
  • To determine if IL-6 gene variations modify HF risk in patients with co-existing CAD and obesity.

Main Methods:

  • A case-control study involving 222 patients with CAD and obesity, compared to 115 CAD patients with normal weight.
  • Analysis of single nucleotide polymorphisms (SNPs) in the IL-6 promoter region, specifically the -174G>C variant.
  • Calculation of odds ratios (OR) and 95% confidence intervals (CI) to assess risk association.

Main Results:

  • The -174G allele and GG genotype were significantly associated with an increased risk of HF in patients with CAD and obesity (OR=2.55 and OR=11.95, respectively).
  • Conversely, the -174C allele demonstrated a protective effect, associated with a decreased risk of HF (OR=0.39).
  • Genotype frequencies differed significantly between groups, highlighting the role of IL-6 polymorphism in HF development.

Conclusions:

  • The -174G>C polymorphism in the IL-6 gene is a significant genetic marker associated with an elevated risk of heart failure.
  • These findings suggest that IL-6 gene variations play a crucial role in the pathogenesis of HF in individuals with CAD and obesity.
Abstract

Keywords:
coronary artery diseaseheart failureobesitythe polymorphisms of the interleukin-6 gene

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