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HEART FAILURE WITH MID-RANGE LEFT VENTRICULAR EJECTION FRACTION

Оlga А Yepanchintseva1, Оleg J Zharinov2, Кyrylo О Mikhaliev3

  • 1HEART INSTITUTE OF THE MINISTRY OF HEALTH OF UKRAINE, KYIV, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|October 15, 2020
PubMed

Insights

Heart failure with mid-range ejection fraction (HFmrEF) shows dynamic systolic function, potentially transitioning between reduced and preserved ejection fraction categories. Individualized management with neurohumoral modulators is crucial for these patients.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Heart failure with mid-range ejection fraction (HFmrEF) represents a distinct clinical pattern.
  • Understanding HFmrEF's epidemiology, pathophysiology, and clinical course is essential for effective patient management.

Purpose of the Study:

  • To review and synthesize current data on HFmrEF.
  • To elucidate the epidemiological, pathophysiological, and clinical characteristics of HFmrEF.

Main Methods:

  • Comprehensive literature search using Google Web Search and PubMed.
  • Analysis of publications from the last decade focusing on HFmrEF.
  • Keywords included: heart failure, left ventricular ejection fraction, mid-range.

Main Results:

  • HFmrEF patients exhibit variable systolic heart function dynamics.
  • There is a potential for transition between HFmrEF, heart failure with reduced ejection fraction (HFrEF), and heart failure with preserved ejection fraction (HFpEF).

Conclusions:

  • Individualized assessment is critical for patients with HFmrEF.
  • Management strategies should involve neurohumoral modulators.
  • Therapeutic interventions aim to prevent left ventricular (LV) dysfunction progression and recurrent HF decompensation.
Abstract

Keywords:
heart failureleft ventricular ejection fractionmid-range

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