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Related Concept Videos

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Classification of Epithelial Tissues: Stratified Epithelium01:29

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Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
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Cells of the Epidermis01:24

Cells of the Epidermis

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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
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Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Apr 3, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

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Superficial epithelioma with sebaceous differentiation.

K J Friedman, S Boudreau, E R Farmer

    Journal of Cutaneous Pathology
    |August 1, 1987
    PubMed
    Summary

    Superficial epithelioma with sebaceous differentiation (SESD) presents as solitary facial papules in older adults. This non-aggressive tumor shows sebaceous cell clusters and does not recur after simple excision.

    Area of Science:

    • Dermatology
    • Oncology
    • Pathology

    Background:

    • Superficial epithelioma with sebaceous differentiation (SESD) is a rare skin tumor.
    • Its histogenesis and clinical behavior require further elucidation.

    Purpose of the Study:

    • To report and characterize five cases of SESD.
    • To describe the clinical and pathological features of SESD.

    Main Methods:

    • Case series reporting.
    • Clinical and histopathological examination of five SESD tumors.

    Main Results:

    • Five solitary SESD papules were observed on the faces of patients aged 57-72.
    • Tumors exhibited superficial, platelike proliferation with basaloid to squamoid cells and mature sebaceous cell clusters.

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  • No recurrences or metastasis were noted after simple excision.

    • Conclusions:

    • SESD is a non-aggressive epithelial tumor with a tendency for sebaceous differentiation.
    • Simple excision appears to be an effective treatment for SESD.
    • Further research into the histogenesis of SESD is warranted.