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Updated: Dec 5, 2025

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Impact of uncomplicated controlled hypertension on thermoregulation during exercise-heat stress
Ashley P Akerman1, Sean R Notley1, Ronald J Sigal2
1Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, ON, Canada.
Abstract:
Exercise is promoted for management of hypertension and as a general healthy behavior, but environmental conditions are seldom considered in these recommendations. Hypertension may affect skin blood flow and sweating, two of the primary mechanisms which prevent continued elevations in core temperature by facilitating whole-body heat loss during exercise-heat stress. We show that during incremental exercise-heat stress (in hot-dry conditions), controlled and uncomplicated hypertension is unlikely to exert a meaningful effect on whole-body heat loss in individuals who are already physically active.
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