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Altered local and distant functional connectivity density in chronic migraine: a resting-state functional MRI study
Lingling Dai1,2, Yang Yu1,2, Hongru Zhao3
1Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow, China.
Chronic migraine disrupts brain network connectivity, particularly in areas for sensory processing and pain modulation. These functional connectivity changes may help assess disease severity.
Area of Science:
- Neuroscience
- Medical Imaging
Background:
- Episodic migraine shows disrupted functional connectivity.
- Chronic migraine's brain network properties remain unclear.
Purpose of the Study:
- Investigate large-scale functional connectivity patterns in chronic migraine.
- Compare chronic migraine patients to healthy controls.
- Explore associations between connectivity and clinical variables.
Main Methods:
- Resting-state functional magnetic resonance imaging (rs-fMRI).
- Voxel-wise functional connectivity density analysis.
- 17 chronic migraine patients vs. 35 healthy controls.
Main Results:
- Decreased connectivity in prefrontal cortex and precuneus.
- Increased connectivity in hippocampal complex, orbital frontal gyrus, and temporal pole.
- Connectivity correlated with headache frequency and pain intensity.
Conclusions:
- Chronic migraine involves altered functional connectivity in key brain regions.
- Local and distant connectivity density are useful biomarkers.
- Connectivity alterations may reflect disease burden.
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