Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Narcolepsy with co-occurring epilepsy: diagnostic pitfalls and management strategy.

Therapeutic advances in neurological disorders·2026

Same author

Chronic sleep deprivation promotes drug-resistant epilepsy via the BMAL1-mTOR-P-gp axis.

Epilepsia open·2026

Same author

Perceived organizational support as a mediator between role clarity and work engagement among neurology specialist nurses: a cross-sectional study.

BMC nursing·2026

Same author

Transcriptional signatures and topological reorganization of morphometric similarity networks in temporal lobe epilepsy with unilateral hippocampal sclerosis.

Epilepsia·2026

Same author

EEG features in late-onset epilepsy: possible correlation with cognitive impairment.

Brain communications·2026

Same author

EEG microstate-derived dynamic network biomarkers for lateralization and structural etiology in temporal lobe epilepsy.

Epilepsia·2026

Search research articles

Related Experiment Video

Updated: Dec 5, 2025

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

Dynamic gray matter and intrinsic activity changes after epilepsy surgery.

Wei Li¹, Yuchao Jiang², Yingjie Qin¹

¹Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.

Acta Neurologica Scandinavica

|October 15, 2020

Summary

Anterior temporal lobectomy (ATL) for mesial temporal lobe epilepsy (mTLE) can cause brain volume and activity changes. These findings reveal brain reorganization after successful epilepsy surgery.

Keywords:

amplitude of low-frequency fluctuations anterior temporal lobectomy gray matter volume longitudinal mesial temporal lobe epilepsy

More Related Videos

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Related Experiment Videos

Last Updated: Dec 5, 2025

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Author Spotlight: Unraveling Seizure Dynamics and Novel Therapeutics for Status Epilepticus Using CMOS High-Density Microelectrode Array Systems

Published on: September 27, 2024

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

Area of Science:

Neuroscience
Neurosurgery
Epileptology

Background:

Mesial temporal lobe epilepsy (mTLE) is a common focal epilepsy.
Anterior temporal lobectomy (ATL) is a surgical option for drug-resistant mTLE.
Understanding post-surgical brain changes is crucial for patient outcomes.

Purpose of the Study:

To investigate dynamic changes in gray matter volume (GMV) and intrinsic brain activity after ATL in seizure-free mTLE patients.
To analyze serial MRI data up to 24 months post-surgery.
To correlate structural and functional brain alterations with epilepsy surgery.

Main Methods:

Serial high-resolution T1-weighted and resting-state functional MRI scans were acquired from 10 mTLE patients.
Data were collected pre-surgery and at 3, 6, 12, and 24 months post-ATL.
Gray matter volume (GMV) and amplitude of low-frequency fluctuations (ALFF) were analyzed to track dynamic changes.

Main Results:

Post-ATL, ipsilateral brain regions showed decreased GMV, with some regions exhibiting progressive atrophy and others a significant reduction at 3 months.
Ipsilateral insula and superior temporal gyrus demonstrated decreased ALFF, while the thalamus and cerebellar vermis showed increased ALFF.
Dynamic changes in GMV and ALFF indicate structural and functional reorganization following successful epilepsy surgery.

Conclusions:

ATL can induce short-term reductions in GMV and intrinsic brain activity in adjacent areas.
Progressive gray matter atrophy may reflect intrinsic mTLE mechanisms.
Dynamic ALFF alterations suggest reorganization of spontaneous brain activity after successful ATL.