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Multilevel regulation and molecular mechanism of poly (rC)-binding protein 1 in cancer

Xuetian Zhang1,2,3,4, Cuixia Di1,2,3,4, Yuhong Chen1,2,3,4

  • 1Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|October 15, 2020
PubMed

Insights

Poly (rC)-binding protein 1 (PCBP1) acts as a tumor suppressor, inhibiting cancer progression and metastasis. Understanding its regulatory roles in gene expression and cancer cell processes offers new therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Poly (rC)-binding protein 1 (PCBP1) is a 38 kDa RNA/DNA-binding protein.
  • PCBP1 is frequently downregulated in various cancer types.
  • Evidence suggests PCBP1 functions as a tumor suppressor, inhibiting cancer initiation, progression, and metastasis.

Purpose of the Study:

  • To review the multifaceted regulatory functions of PCBP1 in cancer.
  • To summarize PCBP1's inhibitory effects on common tumors.
  • To elucidate PCBP1's molecular mechanisms in cancer, including its roles in hypoxic microenvironments, autophagy, apoptosis, and chemotherapy.

Main Methods:

  • Literature review of existing research on PCBP1 in cancer.
  • Analysis of PCBP1's regulatory roles in gene transcription, alternative splicing, and translation.
  • Synthesis of data on PCBP1's involvement in cancer cell biology and response to therapy.

Main Results:

  • PCBP1 regulates gene transcription, alternative splicing, and translation of cancer-related genes.
  • PCBP1 exhibits inhibitory effects against a range of common tumors.
  • PCBP1 plays significant roles in the hypoxic microenvironment, autophagy, apoptosis, and chemotherapy response in cancer cells.

Conclusions:

  • PCBP1 exhibits diverse tumor-suppressive functions.
  • Further investigation into PCBP1's molecular mechanisms is crucial for developing novel cancer therapies.
  • Targeting PCBP1 may offer a promising avenue for cancer treatment.
Keywords:
PCBP1cancer therapygene expressionmechanismstumor suppressor

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