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Updated: Dec 5, 2025

In Vitro Cellular Activity Evaluation of the Nanoemulsion Vaccine Adjuvant Ophiopogonin D
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Ionic-Liquid-Based Safe Adjuvants.

Anvay Ukidve1, Katharina Cu1, Morgan Goetz1

  • 1Wyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.

Advanced Materials (Deerfield Beach, Fla.)
|October 15, 2020
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Summary
This summary is machine-generated.

A novel vaccine adjuvant, choline and lactic acid (ChoLa), derived from the body's own metabolites, enhances immune responses. This safe, ionic-liquid-based adjuvant shows promise for future pandemic preparedness.

Keywords:
adjuvantscholineimmune modulationionic liquidslactic acidvaccines

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Area of Science:

  • Vaccinology
  • Immunology
  • Biomaterials Science

Background:

  • Adjuvants are crucial for vaccine efficacy but few are approved for human use.
  • Existing adjuvants often contain non-native components, raising safety concerns.
  • There is a need for novel, safe, and effective vaccine adjuvant platforms.

Purpose of the Study:

  • To explore a novel ionic-liquid-based adjuvant synthesized from choline and lactic acid (ChoLa).
  • To evaluate the safety and efficacy of ChoLa as a vaccine adjuvant.
  • To assess ChoLa's potential in enhancing immune responses against antigens.

Main Methods:

  • Synthesis of an ionic-liquid adjuvant using choline and lactic acid.
  • Evaluation of ChoLa's properties: antigen distribution, integrity maintenance, and immune cell infiltration.
  • Assessment of the immune response generated by ChoLa-adjuvanted antigens.

Main Results:

  • ChoLa demonstrated efficient antigen distribution and maintained antigen integrity.
  • The adjuvant enhanced immune cell infiltration at the injection site.
  • ChoLa induced a potent immune response when combined with an antigen.

Conclusions:

  • ChoLa is a promising, safe, and effective adjuvant platform derived from endogenous metabolites.
  • This novel adjuvant can enhance vaccine-induced immune responses.
  • ChoLa holds potential for protecting against pandemics and future infectious threats.