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Genetics of COVID-19
1Laboratório Genetika, Curitiba, PR, Brazil; Comitê Científico de Genética, Sociedade Brasileira de Pediatria, Brazil.
Jornal De Pediatria
|October 15, 2020
Summary
This review updates on the genetics of SARS-CoV-2 (the virus that causes COVID-19) and its interaction with the human genome. Understanding viral genetics is crucial for COVID-19 prevention, diagnosis, and treatment strategies.
Area of Science:
- Genetics and Genomics
- Molecular Biology
- Infectious Diseases
Background:
- COVID-19, caused by SARS-CoV-2, has a significant global health impact.
- Understanding the genetic makeup of SARS-CoV-2 is essential for managing the pandemic.
- The virus's interaction with the human genome is a key area of research.
Purpose of the Study:
- To provide an updated overview of the genetic aspects of SARS-CoV-2.
- To explore the implications of SARS-CoV-2 genetics on COVID-19 etiology, prevention, diagnosis, prognosis, and therapy.
- To highlight the role of viral genetics in understanding the evolutionary, clinical, and epidemiological facets of the disease.
Main Methods:
- A narrative, non-systematic review approach was employed.
- Literature search included MEDLINE, BioRxiv, and SciELO databases.
- Internet searches and specific keywords (COVID-19, SARS-CoV-2, genetics, molecular, mutation, vaccine, Brazil) were utilized to gather relevant publications from 2019-2020.
Main Results:
- An expanding body of research demonstrates increasing knowledge of SARS-CoV-2 genetics and genomics.
- Publications reveal the intricate relationship between viral genetics and COVID-19 pathogenesis.
- Data specific to the Brazilian population's molecular epidemiology was sought.
Conclusions:
- Knowledge of the SARS-CoV-2 genome sequence is vital for in-depth investigation of viral proteins and COVID-19 pathophysiology.
- Understanding viral genetics aids in comprehending the evolutionary, clinical, and epidemiological aspects of COVID-19.
- Genomic insights are instrumental in focusing efforts on prevention and treatment strategies for COVID-19.
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