Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.5K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.2K
3.2K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.8K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.8K
MicroRNAs01:22

MicroRNAs

3.5K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.5K
MicroRNAs01:22

MicroRNAs

23.5K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.5K
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

5.9K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Vision-Based Sensing Framework for PPE Detection and Safety Harness Compliance Recognition in High-Formwork Construction Environments Using YOLO-ILB.

Sensors (Basel, Switzerland)·2026
Same author

Targeted co-delivery of curcumin and TRAIL via engineered extracellular vesicles: a synergistic therapy against resistant cancers.

Drug delivery and translational research·2026
Same author

StLecRK. IX and StLRPK1 form a complex with StBAK1 to positively regulate potato late blight resistance.

Plant science : an international journal of experimental plant biology·2026
Same author

Comparative study on typical heavy metal immobilization in cement-based and alkali-activated backfill materials.

Environmental research·2026
Same author

Constructing Mo-O-Ni anchoring bonds by room temperature solid-state reduction to drive hydrogen spillover for saturated hydrogenation of naphthalene.

Chemical communications (Cambridge, England)·2026
Same author

Recovery strategy of platinum group metal ruthenium (Ru) from spent SiC catalyst: Combined process of oxidation roasting and Fe smelting capture.

Waste management (New York, N.Y.)·2026

Related Experiment Video

Updated: Dec 5, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.7K

Long noncoding RNA HOTAIRM1 in human cancers.

Yuqiao Zhao1, Weina Wang2, Canghai Guan1

  • 1Department of General Surgery, The 2nd Affiliated Hospital of Harbin Medical University, No. 148 BaoJian Road, Harbin 150086, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|October 15, 2020
PubMed
Summary

Long noncoding RNAs (lncRNAs) play a role in cancer. HOTAIRM1, a specific lncRNA, is linked to various tumors and may offer therapeutic potential.

Keywords:
BiomarkerCancerHOTAIRM1LncRNA

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

917
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.8K

Related Experiment Videos

Last Updated: Dec 5, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.7K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

917
An Integrated Approach for Microprotein Identification and Sequence Analysis
09:37

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

3.8K

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Long noncoding RNAs (lncRNAs) are key regulators of cellular processes, including those in tumor cells like proliferation, invasion, and apoptosis.
  • Aberrant expression of certain lncRNAs is frequently associated with cancer development, progression, and metastasis.
  • HOTAIRM1, initially identified for its role in granulocytic differentiation, is recognized as a significant cancer-related lncRNA with abnormal expression across numerous malignancies.

Purpose of the Study:

  • To review the current evidence regarding the critical role of HOTAIRM1 in human cancers.
  • To explore the potential mechanisms by which HOTAIRM1 influences malignancy.
  • To discuss the future prospects of HOTAIRM1 in the development of novel cancer therapeutics.

Main Methods:

  • Literature review of existing studies on HOTAIRM1 and cancer.
  • Analysis of reported data on HOTAIRM1 expression patterns in various human tumors.
  • Synthesis of information on the molecular mechanisms underlying HOTAIRM1's function in cancer.

Main Results:

  • HOTAIRM1 is abnormally expressed in a wide range of human malignancies.
  • Evidence suggests HOTAIRM1 plays a critical role in the development and progression of cancer.
  • Specific molecular mechanisms of HOTAIRM1 action in cancer are being elucidated.

Conclusions:

  • HOTAIRM1 is a significant player in human oncogenesis.
  • Understanding HOTAIRM1's mechanisms is crucial for developing targeted cancer therapies.
  • HOTAIRM1 holds promise as a biomarker and therapeutic target for various cancers.