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Do hydrogen peroxide mouthwashes have a virucidal effect? A systematic review
K L Ortega1, B O Rech1, G L C El Haje1
1Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
The Journal of Hospital Infection
|October 15, 2020
Summary
Hydrogen peroxide mouthwash lacks scientific evidence for controlling SARS-CoV-2 or other viruses in saliva. This systematic review found no studies supporting its use to reduce viral load in oral procedures.
Area of Science:
- Oral Medicine
- Infectious Diseases
- Dental Public Health
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in saliva poses a risk of aerosol contamination during dental procedures.
- Preoperative use of 1% hydrogen peroxide mouthwash has been suggested to reduce SARS-CoV-2 viral load, influencing dental protocols.
Purpose of the Study:
- To systematically review the scientific literature to determine if hydrogen peroxide mouthwash, at any concentration, exhibits a virucidal effect.
Main Methods:
- A systematic search was conducted across Cochrane, LILACS, PubMed, Scopus, and Embase databases.
- Keywords included various terms for hydrogen peroxide and mouthwash.
- Exclusion criteria targeted non-relevant study types and formulations not solely containing hydrogen peroxide.
Main Results:
- An initial search identified 1342 articles, reduced to 976 after duplicate removal.
- Only studies evaluating the virucidal effect of hydrogen peroxide mouthwash were considered.
Conclusions:
- No studies met the eligibility criteria for the systematic review.
- There is currently no scientific evidence to support the use of hydrogen peroxide mouthwash for controlling SARS-CoV-2 or other viral loads in saliva.
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