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Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis
Sadichhya Lohani1, Mohanraj Sadasivam2, Hamid Rabb3
1Division of Renal electrolyte and hypertension, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nephron
|October 15, 2020
Summary
Collapsing glomerulopathy may stem from elevated interferon gamma produced by double negative T cells, even with treatment. This finding offers new insights into the disease
Area of Science:
- Nephrology
- Immunology
- Genetics
Background:
- Collapsing glomerulopathy is linked to infections, drugs, autoimmune conditions, and genetics.
- Interferon gamma is a key cytokine implicated in immune responses.
Observation:
- A case of collapsing focal segmental glomerulosclerosis showed persistently high interferon gamma levels.
- These high levels originated from T-cell receptor αβ (+), CD4- CD8- (double negative) T lymphocytes.
Findings:
- Double negative T cells, elevated in autoimmune lymphoproliferative syndrome (ALPS), produced high interferon gamma.
- This production persisted despite treatment and normalization of other cytokine levels.
Implications:
- Elevated interferon gamma from double negative T cells in ALPS may drive collapsing glomerulopathy.
- Understanding this mechanism can guide future research and therapeutic strategies for collapsing glomerulopathy.
Keywords:
Autoimmune lymphoproliferative disorderCollapsing glomerulopathyDouble negative T cellFocal segmental glomerulosclerosisInterferon gamma
