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Related Experiment Video

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Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
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Association between Thyroid Hormones, Apolipoprotein E, and Cognitive Function among Cognitively-Normal Elderly

Beomjun Kim1, Seok Woo Moon1

  • 1Department of Psychiatry, Research Institute of Medical Science, Konkuk University Medical School, Chungju, Republic of Korea.

Psychiatry Investigation
|October 16, 2020
PubMed
Summary

Lower thyroid stimulating hormone (TSH) levels impact memory in cognitively normal elderly. The interaction of TSH and Apolipoprotein E ε4 (APOE ε4) specifically affects semantic memory performance.

Keywords:
APOEAgedCognitive functionMemoryThyroid hormones

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Thyroid hormones and Apolipoprotein E ε4 (APOE ε4) genotype are implicated in cognitive function, but results are conflicting.
  • Understanding these relationships is crucial for identifying early markers of cognitive decline in aging populations.

Purpose of the Study:

  • To investigate the correlation between thyroid hormones, APOE ε4, and cognitive function in cognitively normal elderly individuals.
  • To explore the interplay between TSH levels and APOE ε4 genotype on specific cognitive domains.

Main Methods:

  • Assessed 507 cognitively normal individuals over 60 years old.
  • Conducted comprehensive hematological (serum free thyroxine, TSH) and neuropsychological assessments (verbal fluency, memory tests).
  • Accounted for covariates including age, gender, education, and APOE ε4 status.

Main Results:

  • Significant positive associations were found between TSH levels and scores on verbal fluency (VFT), Word List Memory Test (WLMT), and Word List Recall Test (WLRT).
  • The interaction between APOE ε4 and TSH levels significantly influenced VFT scores, but not WLMT or WLRT scores.

Conclusions:

  • Lower serum TSH levels are associated with impairments in semantic (VFT) and episodic memory (WLMT, WLRT) in the cognitively normal elderly.
  • The interaction of TSH and APOE ε4 specifically affects semantic memory performance in this population.