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[A comparative analysis of the efficacy of two vitamin D supplementation regimens in preterm infants: a prospective

Li Ma1, Li-Meng Geng, Xi-Hui Zhou

  • 1Department of Neonatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. zhouxih@mail.xjtu.edu.cn.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|October 16, 2020
PubMed

Insights

A single intramuscular vitamin D injection significantly improved vitamin D levels in preterm infants by day 28. This method effectively reduced vitamin D deficiency without adverse effects.

Area of Science:

  • Neonatal Medicine
  • Pediatric Nutrition
  • Endocrinology

Background:

  • Preterm infants (<34 weeks gestation) are at high risk for vitamin D deficiency.
  • Establishing optimal vitamin D supplementation for this vulnerable population is crucial for their nutritional status and long-term health.

Purpose of the Study:

  • To compare the efficacy of a single intramuscular vitamin D3 injection versus daily oral vitamin D3 drops on serum 25-hydroxyvitamin D [25(OH)D] levels in preterm infants.
  • To assess the prevalence of vitamin D deficiency and the safety of different supplementation regimens.

Main Methods:

  • 59 preterm infants (<34 weeks gestation) were divided into two groups.
  • Observation group: Single intramuscular dose of vitamin D3 (10,000 IU/kg).
  • Control group: Oral vitamin D3 drops (900 IU/d) for 25 days. Serum 25(OH)D levels were measured at birth and on day 28.

Main Results:

  • Initial vitamin D deficiency prevalence was 78% in all infants.
  • On day 28, the intramuscular group showed significantly higher serum 25(OH)D levels compared to the oral group.
  • The intramuscular injection significantly reduced the prevalence of vitamin D deficiency, with no reported overdose or toxicity.

Conclusions:

  • A single intramuscular dose of 10,000 IU/kg vitamin D3 is a safe and effective strategy.
  • This regimen significantly improves vitamin D nutritional status in preterm infants by day 28.
  • Intramuscular vitamin D supplementation offers a promising alternative for preventing deficiency in this population.
Abstract

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